Squamous Cell Carcinoma
Squamous cell carcinoma (SCC) is the second most common skin cancer. Unlike BCC, SCC carries a meaningful risk of metastasis if neglected.
Symptoms
Firm, red, scaly nodule or plaque, often with a central ulcer or crust. Bleeds easily and grows steadily. Common on ears, lower lip, scalp, and backs of hands.
Causes and risk
Cumulative UV exposure and actinic keratoses as precursors. Immunosuppression, chronic wounds, HPV, radiation, and smoking (lip SCC) are additional risk factors.
How it is evaluated
Biopsy is required. We assess differentiation grade, depth, perineural involvement, and tumor size for risk stratification. Imaging for high-risk tumors.
Treatment
Excision with appropriate margins is first-line. Mohs surgery for high-risk or cosmetically sensitive SCCs. Radiation when surgery is not feasible. Our Chicago team coordinates treatment and close follow-up.